Take I-40 West to Exit 27 (23 South/74 West). Stay on 23/74 to Exit 81 (U.S. 441/23 South). Approximately 18 miles to Franklin from this exit. Approximately 65 miles.
Follow I-85 North to I-985. Left on I-985 which becomes 23/365 North. 23/365 becomes 23/441 North. Follow straight into Franklin. Approximately 125 miles.
From Greenville, SC:
Take I-85 South to Exit 19 (Clemson). Follow 76 West to Clayton, Georgia. Take U.S. 441 North straight to Franklin. Approximately 110 miles.
From Knoxville, TN:
Interstate: I-40 East to Exit 20 (Hwy 276 South). Stay south on 276 until reaching 23/74 South. Follow to Exit 81 (U.S. 441/23 South). Approximately 18 miles to Franklin from this exit. Approximately 130 miles.
Scenic: Take U.S. 441 South from Knoxville to Sevierville (approximately 25 miles). Remain on 441 South to Pigeon Forge/Gatlinburg. Take by-pass around Gatlinburg. Remain on 441 South through the Great Smoky Mountains National Park to Cherokee. Stay on 441 South to Franklin (35 miles from Cherokee). Approximately 110 miles.